Chronic pelvic pain syndrome (CPPS), defined as continuous or recurrent pain in the pelvic region lasting at least six months, which cannot be wholly attributed to a single organ or distinct pathology, 1 has a multifactorial etiology involving the gynecologic, urologic, gastrointestinal, musculoskeletal and/or neurologic systems. Aberrant pain signal processing and local tissue responses are contributive factors.

Objectives: Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a debilitating condition characterized by bladder/pelvic pain and pressure as well as persistent or recurrent urinary symptoms in the absence of an identifiable cause. It is hypothesized that in addition to organ specific visceral hypersensitivity, contributions of the hypertonic pelvic floor, peripheral sensitization, and central sensitization exacerbate this condition.

Chronic Pelvic Pain (CPP) is a complex, multifaceted condition that affects both women and men. There is limited literature on the cost utilization the healthcare system and CPP patients incur. The purpose of this analysis is to characterize the overall healthcare utilization, cost burden, and quality-of-life restrictions experienced by CPP patients using data from an outpatient pelvic rehabilitation practice.

Abstract
Endometriosis is a chronic inflammatory disease. Pain is the most common symptom in endometriosis. Endometriosis-associated pain is caused by inflammation, and is related to aberrant innervation. Although the specific mechanism between endometriosis-associated pain and the interaction of aberrant innervation and inflammation remains unclear, many studies have confirmed certain correlations between them.

Chronic pelvic pain (CPP) is described by the American College of Obstetricians and Gynecologists as noncyclic “pain symptoms perceived to originate from pelvic organs or structures typically lasting more than 6 months” or cyclical pain that has “significant cognitive, behavioral, sexual, and emotional consequences.”

Background: Urological chronic pelvic pain syndrome (UCPPS) combines two of the most widespread chronic urological pain disorders: interstitial cystitis (IC)/bladder pain syndrome (BPS) and chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS). This manuscript aims to assess the effectiveness of an outpatient, multimodal treatment protocol for men with UCPPS.

Chronic pelvic pain (CPP) is one of the most common pain conditions suffered by women and can severely affect the quality of life, including physical functioning, psychological wellbeing, and interpersonal relationships. The estimated prevalence for women of reproductive ages is between 14% – 24%, and about 14% of women experience CPP during their life [1,2]. CPP syndrome in women is multi-faceted with interconnections between organ systems, musculature, fascia, and the peripheral and central nervous system.

Chronic pelvic pain syndrome (CPPS), a multifactorial, debilitating condition combining the anatomic malfunction of pelvic floor musculature and malfunction of pain perception.1 The noncyclical pain restricts function and is persistent for more than 6 months. Applying this rigorous definition of “noncyclical pain lasting at least 6 months,

1. Introduction
Endometriosis is a chronic, benign gynecological illness associated with infertility and pelvic pain. Despite having insufficient epidemiological data, it affects approximately 10% of women in their reproductive age.

Endometriosis is quite a common gynecological disease, which is difficult to diagnose and treat. It affects about 10% of young women, which represents approximately 200 million women of reproductive age [1]. That number increases up to 50% in the group of patients with chronic pelvic pain, infertility, or both [2]. The common symptoms of endometriosis are dysmenorrhea, dyspareunia and back pain, as well as bladder and/or bowel problems, which may vary in degree and intensity [1]. These symptoms are usually nonspecific, which makes the clinical diagnosis of the disease very difficult.

Chronic Pelvic Pain (CPP) is characterized by noncyclical pain in the pelvis or abdomen present for 3–6 months, interfering with daily function.1 CPP is also known as Urological Chronic Pelvic Pain (UCPPS) and Chronic Pelvic Pain Syndrome (CPPS),2 for the purposes of this study, CPP will be the consistent nomenclature.

We published a manuscript entitled “A Novel, Non-opioid Treatment for Chronic Pelvic Pain in Women with Previously Treated
Endometriosis Utilizing Pelvic-Floor Musculature Trigger-Point Injections and Peripheral Nerve Hydrodissection”. There is
little consensus in the literature on the underlying etiology of endometriosis.

Endometriosis resulting in neuropathic pain may occur due to invasion of endometriosis into pelvic nerves or spontaneous pain resulting from compression of pelvic nerves including the obturator, pudendal, ilioinguinal, iliohypogastric, genitofemoral, or lateral femoral cutaneous nerve.

Chronic Pelvic Pain Syndrome (CPPS) is a complex, multi-faceted disease complex. CPPS is defined as pain associated with any pelvic structure that persists or recurs for at least 6 months and is not the direct result of a single, obvious, local pathology [1]. CPPS is one of the most prevalent gynecologic conditions affecting over nine million women in the United States [2].

Urological chronic pelvic pain syndrome (UCPPS) is newer nomenclature that has combined chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis, which are two of the most prevalent chronic urological pain disorders. According to the NIH, urologic chronic pelvic pain syndrome is broken down into four categories: acute bacterial prostatitis, chronic bacterial prostatitis, chronic pelvic pain syndrome, and asymptomatic inflammatory prostatitis.1 UCPPS affects 2% to 16% of men worldwide.