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Endometriosis and the Inflammatory Cascade

Endometriosis is an often serious disorder in which the lining of the uterus grows outside of the uterus. While the cause of endometriosis is unknown, the impact on patients’ health can be severe. The pH balance of the tissues can be disrupted and the muscles and nerves can be put into disarray. Neurotransmitters begin stimulating an inflammatory cascade that can cause chronic pain.

Understanding Endometrial Lesions

Endometrial lesions are typically located in the pelvis, but they can occur at other locations, including the bowel and diaphragm. Endometriosis is fairly common and can cause a number of serious conditions as well as chronic pain and infertility. Symptoms range from minor to severely debilitating.


Relief from Endometriosis Pain : Patient Testimonial

Why Is Endometriosis So Painful?

  1. Endometriosis plaques can directly invade nerves
  2. Endometriosis can cause pelvic floor muscle spasms
  3. The presence of Endometriosis can stimulate the inflammatory cascade which can lead to peripheral nerve neurogenic inflammation and pain as well as contribute to the process of central sensitization

Whole Body Approach to the Complications of Endometriosis

Unfortunately, endometriosis may also be an indicator of a larger issue. Medical experts consider it likely that the disease involves an abnormality in the immune response. The inflammatory nature of the disease was noted more than a decade ago and a study published in the journal Human Reproduction in 2007 explored endometriosis’ inflammatory aspects. The results of this study suggest that endometriosis is a disease involving complex inflammatory behavior, possibly including an auto-immune component.

When dealing with an auto-immune condition – in which the body seems to be attacking itself – we believe our “whole body” approach stands a great chance of success. And, we’re pleased to say that our results often bear out this conclusion.

ROSE: Research OutSmarts Endo

ROSE-Research-OutSmarts-Endometriosis Logo

You can help.

Pelvic Rehabilitation Medicine has Partnered with Northwell Health's Feinstein Institute to further endometriosis diagnosis. Click to see how you can help the study.


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